A transgenic Drosophila melanogaster model to study 1 Human T - Lymphotropic Virus oncoprotein Tax - 1 - driven 2 transformation in vivo
نویسندگان
چکیده
1 Department of Experimental Pathology Immunology and Microbiology Faculty of 8 Medicine, American University of Beirut, Beirut, Lebanon 9 10 2 Department of Biology, American University of Beirut, Beirut, Lebanon 11 12 3 Department of Internal Medicine, Faculty of Medicine, American University of Beirut, 13 Beirut, Lebanon 14 15 4 Department of Molecular Biology, Umea University, Building 6L, SE-901 87 Umea, 16 Sweden 17 18 5 Equipe Oncogenèse Rétrovirale, Lyon, Cedex 07, France 19 20 6 Equipe labellisée “Ligue Nationale Contre le Cancer”, Lyon, Cedex 07, France 21 22 7 Centre international de recherche en infectiologie, INSERM U1111 CNRS UMR5308, 23 Lyon, Cedex 07, France 24 25 8 INSERM U1111 Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364 Lyon, 26 Cedex 07, France 27 28 JVI Accepted Manuscript Posted Online 20 May 2015 J. Virol. doi:10.1128/JVI.00918-15 Copyright © 2015, American Society for Microbiology. All Rights Reserved.
منابع مشابه
A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo.
Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-κB. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but...
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HTLV-1 cellular transformation and disease induction is dependent on expression of the viral Tax oncoprotein. PDZ is a modular protein interaction domain used in organizing signaling complexes in eukaryotic cells through recognition of a specific binding motif in partner proteins. Tax-1, but not Tax-2, contains a PDZ-binding domain motif (PBM) that promotes the interaction with several cellular...
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Human T-lymphotropic virus type I (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 viral transactivator/oncoprotein, Tax, activates viral transcription and usurps regulatory mechanisms that are critical for cell growth and division to facilitate viral replication. The effects that Tax exerts...
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Expression of the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation, contributing to the development of adult T-cell leukemia. In this study, we investigated the role of Tax in the regulation of the ZNF268 gene, which plays a role in the differentiation of blood cells and the pathogenesis of leukemia. We demonstrated that ZNF268 mRNA was repr...
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